Clearly disconsolate and in a lot of pain, Liverpool's top scorer this season and the reigning PFA Player of the Year was replaced by English midfielder Adam Lallana then.
Bale scored an insurance goal in the 84th minute, with help from Karius.
In a statement released on Saturday evening after the final, Egypt's FA revealed that their team doctor has been informed by Liverpool's medical staff that they are optimistic that Salah has not suffered a tear in his muscle and should be able to feature at the World Cup.
Bale's jaw-dropping overhead kick in the 64th minute put Real 2-1 up moments after his introduction, following a dramatic start to the second half, in which Karim Benzema gave Real the lead as a result of a Loris Karius howler.
Liverpool fans will point to three things that cost their club the Champions League final-superstar striker Mohamed Salah's shoulder injury and two bad mistakes by goalkeeper Loris Karius.
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It may lead to a life-threatening condition called methemoglobinemia when oxygen in the blood dips to dangerously low levels. The agency has been warning about the product for a decade but said reports of illnesses and deaths have continued.
Had Salah been fit to stay on the pitch, it could have been a different story.
In fact, in just two and a half years as coach of Real Madrid he has won the Champions League more times than legendary coaches like Sir Alex Ferguson, Pep Guardiola, Jose Mourinho, Vicente Del Bosque, Jupp Heynckes, Ottmar Hitzfeld and Arrigo Sacchi.
Klopp's side really could have let their heads drop, and yet they were soon back level, Mané turning the ball in after Dejan Lovren headed down James Milner's corner.
Ramos was jeered throughout the match after what was a devastating blow for the Liverpool fans.
Bale said afterwards that he has not played as much as he would have liked this season and he will discuss his future with his agent Jonathan Barnett in the close-season.