Police said a number of WW2 bombs had found in this area earlier too.
The British bomb has been removed, the main railway station has reopened and traffic is getting back to normal.
United Kingdom bomb, which is now being defused, was found at Heidestrasse street, after which police ordered all the buildings located within a 800-meter (over 2,600 feet) radius of the explosive to be evacuated, Der Tagesspiegel media outlet reported. But not generally this close to the city center, we're 300-400 meters from the main train station.
However, they added there was no immediate danger because of the bomb.
The deactivation of the bomb is scheduled to begin at 11.30am but it is not known how long it will take.
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Police tweeted a photo of their bomb disposal team poised to make it safe.
Germany still discovers more than 2,000 tonnes of live bombs and munitions every year. Berlin was reduced to ruins in 1945 and about 3000 unexploded bombs are believed to be still lying buried in the city. Many thousands of residents and employees will have to stay clear of, or leave the area by 9:00 am local time (0700 GMT), and not return until the bomb is safely defused.
Flights from Berlin's Tegel airport are not affected but passengers have been warned that public transport to the city's two airports - Tegel and Schoenefeld - would be disrupted.
Thousands of people around Berlin's central railway station were evacuated on Friday to allow disposal experts to defuse an unexploded World War II bomb unearthed on a building site.