Without going into detail, the 34-year-old said he was "done" in a text to The Associated Press shortly after SportsIllustrated.com reported Incognito was "strongly considering retiring", but would consider returning for one more season at the right price.
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Bills' running back LeSean McCoy tweeted he would give Incognito $300,000 to stay with the team. 'My stomach was just constantly upset through these last two years - constipation, basic, little [stuff] right?.
Incognito's recent pay cut reduced his base salary from $6.3 million to $3.7 million, but he received a $1 million bonus as part of the restructure.
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Speculation regarding Incognito's future first began last week after he fired his agent on Twitter.
"It's been a long career", the four-time Pro Bowler told the News from his home in Arizona.
Incognito completed his third season with the Bills, who provided him a second chance at continuing his career.
Incognito told Carucci that his liver and kidneys are "shutting down", so his best option might be to walk away from football. Went to the doctor. "Nothing I can't restore with some balance, but the stress is killing me".
In 2013, Incognito was suspended by the Dolphins for misconduct related to the treatment of teammate Jonathan Martin. After suiting up for 11 seasons in the National Football League, he's near the end.
The Bills must now weigh the gravity of losing the entire left side of their offensive line - from center to tackle - since the end of the 2017 season.