Liverpool take a 3-0 lead to the Etihad for the second leg of the quarter-final and are firmly in the driving seat after a wonderful display at Anfield.
The Egyptian worldwide picked up a groin injury during the 3-nil win over City at Anfield last week, and sat out the weekend's Merseyside derby.
Alex Oxlade-Chamberlain - Liverpool: The "Ox" did not have much of an influence on the Merseyside derby, but prior to that, he produced another top-notch performance versus Guardiola's men.
Like Manchester City, the Reds boss Jurgen Klopp decided to make five changes to the starting lineup, and this reduced their usual attacking threat.
The Sunday Supplement panel assess what went wrong for Manchester City following their 3-2 defeat to Manchester United. Like I said, we want to win the game'. Create a lot of chances and be clinical when you create those chances.
'We defend pretty well, very compact.
"It was a tough week for us, two defeats in a week, but that's in the past already", said the Brazilian.
"We see what happens".
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"They have it most consistently, that is why they will be (league) champions, but we know they can concede goals".
City suffered defeats in back-to-back games for the first time this term as they succumbed to a 3-2 derby defeat at the hands of cross-town rivals Manchester United.
And Karius is confident that the Reds should follow the same game plan to see them past Pep Guardiola's stricken champions-elect and into the semi-finals. In the first half we had our moments, but in the second half it wasn't good enough.
'We have played well against them.
"Of course, to go through you have to play nearly the ideal game", he told a news conference.
"They are a top team, we know that".