However, there's no Chris Gayle, Jason Holder, Devendra Bishoo, Carlos Brathwaite and Shai Hope.
It's an opportunity for them to stake claims for regular spots, and play alongside the likes of Marlon Samuels, Samuel Badree, Andre Fletcher, Rovman Powell and Kesrick Williams.
The other two matches in the series take place on Monday and Tuesday.
CWI Director of Cricket Jimmy Adams and President and CEO of West Indies Players' Association (WIPA) Wavell Hinds will accompany the squad during the visit.
The visiting team will not be taking part in any practice session before the first game on Sunday evening.
Doubt also remains over the availability of Sunil Narine after he was reported for an illegal action during the Pakistan Super League this month, while Kieron Pollard will be similarly in doubt after pulling out of the T20 series in New Zealand last December and also making himself unavailable for the qualifiers. "We are really happy that we will be playing an global match at our home ground after so many years and are confident to perform well".
That's because the 13-man West Indies squad which was announced late on Thursday night will land in Karachi on Saturday night less than 24 hours before the opening T20I game.
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The last time worldwide cricket was played at Karachi's National Stadium was in 2009, a Test match between Pakistan and Sri Lanka. "I have been working on my bowling". West Indies have not travelled with a media officer.
Hussain Talat, PSL champions Islamabad United's left-handed batsman, is in line to make his global debut during the West Indies T20Is and he thinks he is ready for it. "I have a feeling that this will be a good series for me if I get a chance in the final eleven", said Talat. "That is what the attitude of every player should be".
The biggest name to miss the three-T20I series is Brathwaite, who opted out due to security concerns.
The West Indies will become only the third global team to play a bilateral series on Pakistani soil since a militant attack on the Sri Lankan team bus in Lahore in March 2009.
David Boon, one of the International Cricket Council (ICC) match referees, will supervise the series while Geoff Allardice, the ICC general manager cricket, and Adrian Griffith, the umpires' manager, will also attend the matches to oversee arrangements.
"We have made it very clear to the players and support staff that had personal reservations about this tour that we fully understand and respect their position".