"He's untouchable, you need to understand that and try to create situations in training that fit around him and from there pick a side with a view to that", Sampaoli told a news conference on Monday.
The country last lifted the trophy in 1986 when Diego Maradona was named player of the tournament.
The Juventus star has previously stated has admitted that he has struggled to link up with Messi because the Argentina stars play so similarly.
"We always take each World Cup as a big opportunity, and now more than ever because an important generation will move on, several players will change", Messi said, ahead of Tuesday's friendly against Spain in Madrid.
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Sampaoli insisted he was not gambling over his captain's fitness by fielding Messi against Spain. With FC Barcelona also in league action on Saturday, Sampaoli will not risk his star player. "If I would hit that ball in some other way, maybe like I did against Chelsea the other day from a similar position", added Messi.
"Leo has to play like he does for his club, to put him into another structure is madness".
National teams are using the Adidas Telstar 18 for the first time during the current round of internationals and the lack of grip and excessive movement through the air has been criticised. On the right we can cut in and have the whole pitch in front of us.
'At Juventus he plays just like me, we look for the same spaces.
Argentina face Spain in Madrid tonight.