In Aguero, they not only have the third-highest scorer in the top flight, but also a striker in good form this year.
The 58-year-old steered Chelsea to a league and FA Cup double in his first season in charge after replacing Luiz Filipe Scolari in the summer of 2009.
The England global was involved in the north London derby on numerous occasions as he played 229 matches for Tottenham in eight years at the club.
"Lacazette had knee surgery and he won't be available for the Europa League game unfortunately".
Aguero's record against Arsenal is mixed to say the least, with an even share of wins, draws and defeats from his 12 meetings against the Gunners during his time with Man City. They will though, benefit from the recent return of Sane and Silva.
Arsenal goalkeeper Petr Cech has claimed that David Ospina is likely to start in between the sticks for Sunday's EFL Cup final against Manchester City at Wembley. "Otherwise I would certainly have played him in the Europa League against Östersunds". It's his favoured position and one that Wenger sees him in going forward.
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The midfielder trained with his team-mates on Wednesday morning but a groin injury means he will not feature against Ostersund and is still a doubt for the meeting with Manchester City.
The Gunners thrashed Ostersunds 3-0 in the first leg at the Jamtkraft Arena thanks to goals from Nacho Monreal, Mesut Ozil and an own goal from Sotirios Papagiannopoulos.
Yet Wenger rejected talk of focusing on the Europa League, describing it as "one of the priorities" rather than their main target. They dont always follow form.
'Maybe sometimes, teams can lose two, three times in a row and we win our games so anything is possible.
Walker has helped City to piece together a Premier League title bid and Champions League challenge, while also chasing down League Cup success. They won the game played at Wembley. It would be absolutely stupid of us to think we can go out there and have a stroll.