City were not done as Aguero grabbed his fourth goal and 21st of the season in the league, smashing his effort into the back of the net from 25 yards to make it 5-1.
De Bruyne was again the creator for Man City's second at the start of the second half.
It's now 19 wins from 20 games at the Etihad Stadium and City need just seven victories from their last 11 matches for Guardiola to confirm his first ever Premier League title. The Foxes got their reward in the 24th minute, when Jamie Vardy pounced on a Kyle Walker giveaway, beat Aymeric Laporte and finished into the corner.
Four goals probably outweighs three assists, but De Bruyne's vision and creativity was on a different level against Leicester, and City fans loved the 26-year-old stealing the match-ball as a joke.
It's more than a game for Korea
At the opening ceremony for the Games, Mr Pence , Kim Yo-jong and Kim Yong-nam were seated in close proximity to each other. International Olympic Committee President Thomas Bach called it "a very emotional moment", one that gave him "goosebumps".
"It was always going to be a matter of time before he overtook my goal tally".
Mahrez returned as a substitute for Leicester after more than a week in self-imposed exile following the collapse of a move to City, and he likely watched on in awe as Pep Guardiola's side ran riot.
After 77 minutes Aguero completed his hat trick in style, chipping home after intercepting Schmeichel's disastrous attempt to pass the ball out of his own area, and then blasted home his fourth from the edge of the box in the final seconds.
"After they scored we were destabilized and we could have conceded one or two more but in the final part we should have come back to 1-1, that makes it hard to swallow", he said.
A bad mistake from Kasper Schmeichel gifted Aguero his hat-trick goal. Kasper Schmeichel's pass to his defender was slow and off the mark, and Aguero stole the ball easily and lobbed it over Schmeichel's head to complete his hat-trick.
Aguero saved the best for last, though, with a sensational dipping shot that crashed in off the underside of the crossbar. He has also contributed an impressive two goals and four assists from central defence, making him a top attacking threat.