With two scoring grabs, Texans WR DeAndre Hopkins matched his franchise single-season record of 11 touchdown receptions set in 2015. He ripped off a 31-yard run before halftime that helped the 49ers get into field-goal range.
The 49ers second touchdown drive came in the third quarter and spanned just 6 plays and 3:33.
T.J. Yates replaced Savage in the game and led touchdown drives on his first two possessions. When Savage returned to the game moments later, it drew an angry response from the founding CEO of Concussion Legacy Foundation on Twitter.
Hopkins had 149 yards receiving and two touchdowns, but lost a fumble in the fourth quarter with the Texans down by 7.
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Texans coach Bill O'Brien is likely to face tough questioning on why Savage was allowed to return so quickly, particularly in a sport where concussion issues have been so much under the spotlight in recent times.
Rookie Deshaun Watson took over at halftime of Houston's season-opener after Savage struggled and made the offense one of the NFL's most potent in six starts, but he tore his anterior cruciate ligament in practice on November 2.
The Texans later released a statement and announced that Savage had indeed suffered a concussion and would not return to the game. Foster remained down for a minute before jogging off the field. He was back on the next series and did not miss a snap.
-Right tackle Trent Brown was declared inactive for the game after going through limited practice last week with a shoulder condition.
-Former Texans defensive lineman Earl Mitchell made an impact early in the game when he stopped Miller for a 2-yard loss on a fourth-and-1 play from the 49ers' 40-yard line.