However, the BMJ research, which drew on over 200 studies, found coffee to be associated with lower risk of some cancers, diabetes, liver disease and dementia. Coffee is available to all people drink, so its use can be a simple method of prevention of liver diseases, which often lead to death.
There was less evidence for the effects of drinking decaffeinated coffee, but it had similar benefits, they said.
The full statement from BMJ follows below.
"That said, our results suggest moderate coffee drinking - up to around three cups per day - is not detrimental to your health, and that incorporating coffee into your diet could have health benefits".
While most researchers can not agree on a definitive list to detail the benefits of coffee, they point out that three cups a day is a safe bet.
Researchers warned that drinking coffee could be bad for pregnant women and added that it was also linked to a very small increased risk of fracture in women.
Dr. Poole and colleagues examined 201 meta-analyses of existing observational studies, and 17 meta-analyses of clinical trials.
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The authors conclude that coffee drinking "seems safe within usual patterns of consumption, except during pregnancy".
Coffee is one of the world's most commonly consumed drinks, with an estimated 2.25billion cups drank around the world each day.
Increasing consumption to above that amount was not associated with harm, but the beneficial effects were less pronounced.
Coffee drinkers also appeared to have lower risks for heart disease.
They wrote: 'Coffee is highly consumed worldwide and could have positive health benefits, especially in chronic liver disease.
"The evidence is so robust and consistent across studies and health outcomes, however, that we can be reassured that drinking coffee is generally safe", he continues. Women seem to benefit more than men with higher levels of consumption if factors like mortality from cardiovascular and coronary heart diseases are considered.
However, it's worth noting that drinking a lot of coffee can also be detrimental to your health. But they insist the findings prove moderate coffee consumption is safe, and more than likely to be good for you.